The answer is YES, but…
you need to make sure that your motherboard supports multi-gpu or SLI/CrossFireX.
Every mainstream cpu like i5 8600k or i7 8700k supports 16 pci-e lanes. That means, that they are prepared to utilize one GPU as common, or SLI/CF configuration with dual-GPU setup at 8-8 configuration. The next level CPUs are LGA 2xxx which are suposed to do heavy multitasking have support for more pci-e lanes. In example the i7 5930k supports 40 lanes I believe. With support of 40 pci-e lanes we can make 16-16 configuration that is going to be utilised well by the CPU. For The AMD side we have support for 64 pci-e lanes, so 4-way SLI/CF(for short) with 100% utilisation. Afterwards everything depends on driver optimisation from AMD and optimising work from app’s developers.
I forgot to say that you need two pci-e slots on your motherboard and good cooling. Also your CPU shouldn’t bottleneck your GPUs, if you want the most from your system.